Assessment of estimated low-density lipoprotein-cholesterol (LDL-c) equations: a systematic review and meta-analysis

Abstract Background Low-density lipoprotein cholesterol (LDL-c) is the major determinant of cardiovascular disease burden. This study critically reviewed published literature and performed a meta-analysis to compare determine which other equations provide best means estimating LDL-c in clinical settings. Method English articles indexed PubMed, Science Open, Biomed central SpringerLink databases were searched with searches being conducted or after 2001 up date. According predefined inclusion exclusion criteria, 22 out 17,970 retrieved eligible for quantitative analysis. Data pooled using random-effects model, results are described as event rates (pooled correlation coefficient). Main body abstract All twelve showed positive respective direct low-density lipoprotein-cholesterol measurements. The estimates stronger between Martin’s equation measurement [0.96 (95% CI 0.94–0.98)] compared Friedewald’s method [0.94 0.92–0.96)]. At triglycerides levels > 400 mg/dl, established better performance (77.78%) than equation. In studies where mg/dl excluded still (83.33%) Short conclusion Our data suggest that Friedewald can serve more accurate estimate especially situations same racial background.